Angelicin inhibits the malignant behaviours of human cervical cancer potentially via inhibiting autophagy
Identifieur interne : 000A88 ( Main/Exploration ); précédent : 000A87; suivant : 000A89Angelicin inhibits the malignant behaviours of human cervical cancer potentially via inhibiting autophagy
Auteurs : Yiran Wang [République populaire de Chine] ; Yueqi Chen [République populaire de Chine] ; Xuedan Chen [République populaire de Chine] ; Yan Liang [République populaire de Chine] ; Dapeng Yang [République populaire de Chine] ; Jiao Dong [République populaire de Chine] ; Neng Yang [République populaire de Chine] ; Zhiqing Liang [République populaire de Chine]Source :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2019.
Abstract
Angelicin is an active compound isolated from the Chinese herb
Url:
DOI: 10.3892/etm.2019.7985
PubMed: 31602210
PubMed Central: 6777310
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yueqi" sort="Chen, Yueqi" uniqKey="Chen Y" first="Yueqi" last="Chen">Yueqi Chen</name><affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-7985">Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xuedan" sort="Chen, Xuedan" uniqKey="Chen X" first="Xuedan" last="Chen">Xuedan Chen</name><affiliation wicri:level="1"><nlm:aff id="af3-etm-0-0-7985">Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Yan" sort="Liang, Yan" uniqKey="Liang Y" first="Yan" last="Liang">Yan Liang</name><affiliation wicri:level="1"><nlm:aff id="af4-etm-0-0-7985">Department of Respiratory Medicine, The General Hospital of PLA Rocket Force, Beijing 100088, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yueqi" sort="Chen, Yueqi" uniqKey="Chen Y" first="Yueqi" last="Chen">Yueqi Chen</name><affiliation wicri:level="1"><nlm:aff id="af2-etm-0-0-7985">Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xuedan" sort="Chen, Xuedan" uniqKey="Chen X" first="Xuedan" last="Chen">Xuedan Chen</name><affiliation wicri:level="1"><nlm:aff id="af3-etm-0-0-7985">Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Yan" sort="Liang, Yan" uniqKey="Liang Y" first="Yan" last="Liang">Yan Liang</name><affiliation wicri:level="1"><nlm:aff id="af4-etm-0-0-7985">Department of Respiratory Medicine, The General Hospital of PLA Rocket Force, Beijing 100088, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Respiratory Medicine, The General Hospital of PLA Rocket Force, Beijing 100088</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Yang, Dapeng" sort="Yang, Dapeng" uniqKey="Yang D" first="Dapeng" last="Yang">Dapeng Yang</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7985">Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Jiao" sort="Dong, Jiao" uniqKey="Dong J" first="Jiao" last="Dong">Jiao Dong</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7985">Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Neng" sort="Yang, Neng" uniqKey="Yang N" first="Neng" last="Yang">Neng Yang</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7985">Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Zhiqing" sort="Liang, Zhiqing" uniqKey="Liang Z" first="Zhiqing" last="Liang">Zhiqing Liang</name><affiliation wicri:level="1"><nlm:aff id="af1-etm-0-0-7985">Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Obstetrics and Gynecology, Southwest Hospital, Third Military Medical University, Chongqing 400038</wicri:regionArea><wicri:noRegion>Chongqing 400038</wicri:noRegion></affiliation></author></analytic><series><title level="j">Experimental and Therapeutic Medicine</title><idno type="ISSN">1792-0981</idno><idno type="eISSN">1792-1015</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Angelicin is an active compound isolated from the Chinese herb <italic>Angelica archangelica</italic>, which has been reported to exert antitumor effects by inhibiting malignant behaviors in several types of tumor, including proliferation, colony formation, migration and invasion. However, the effects of angelicin on human cervical cancer cells is yet to be elucidated. The present study evaluated the antitumor effects of angelicin on cervical cancer cells. The results demonstrated that cervical cancer cells were more sensitive to angelicin than cervical epithelial cells. At its IC<sub>30</sub>, angelicin inhibited the proliferation of HeLa and SiHa cells by blocking the cell cycle at the G1/G0 phase and inhibiting other malignant behaviors, including colony formation, tumor formation in soft agar, migration and invasion. At the IC<sub>50</sub>, angelicin induced cell death potentially by promoting apoptosis. By identifying the hallmarks of autophagy, it was observed that angelicin treatment caused the accumulation of microtubule associated protein 1 light chain 3-β (LC3B) in the cytoplasm of HeLa and SiHa cells. Western blotting results demonstrated that cleaved LC3B-II and autophagy related proteins (Atg)3, Atg7 and Atg12-5 were upregulated following angelicin treatment. It was also determined that the phosphorylation of mTOR was induced by angelicin treatment. Furthermore, the inhibition of angelicin-induced mTOR phosphorylation did not disrupt its inhibitory effect on autophagy, indicating that angelicin inhibited autophagy in an mTOR-independent manner. Taken together, the present results suggested that angelicin regulated malignant behaviors in cervical cancer cells by inhibiting autophagy in an mTOR-independent manner. 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Ohsumi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hara, T" uniqKey="Hara T">T Hara</name></author><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choi, H" uniqKey="Choi H">H Choi</name></author><author><name sortKey="Merceron, C" uniqKey="Merceron C">C Merceron</name></author><author><name sortKey="Mangiavini, L" uniqKey="Mangiavini L">L Mangiavini</name></author><author><name sortKey="Seifert, El" uniqKey="Seifert E">EL Seifert</name></author><author><name sortKey="Schipani, E" uniqKey="Schipani E">E Schipani</name></author><author><name sortKey="Shapiro, Im" uniqKey="Shapiro I">IM Shapiro</name></author><author><name sortKey="Risbud, Mv" uniqKey="Risbud M">MV Risbud</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Yiran" sort="Wang, Yiran" uniqKey="Wang Y" first="Yiran" last="Wang">Yiran Wang</name></noRegion><name sortKey="Chen, Xuedan" sort="Chen, Xuedan" uniqKey="Chen X" first="Xuedan" last="Chen">Xuedan Chen</name><name sortKey="Chen, Yueqi" sort="Chen, Yueqi" uniqKey="Chen Y" first="Yueqi" last="Chen">Yueqi Chen</name><name sortKey="Dong, Jiao" sort="Dong, Jiao" uniqKey="Dong J" first="Jiao" last="Dong">Jiao Dong</name><name sortKey="Liang, Yan" sort="Liang, Yan" uniqKey="Liang Y" first="Yan" last="Liang">Yan Liang</name><name sortKey="Liang, Zhiqing" sort="Liang, Zhiqing" uniqKey="Liang Z" first="Zhiqing" last="Liang">Zhiqing Liang</name><name sortKey="Yang, Dapeng" sort="Yang, Dapeng" uniqKey="Yang D" first="Dapeng" last="Yang">Dapeng Yang</name><name sortKey="Yang, Neng" sort="Yang, Neng" uniqKey="Yang N" first="Neng" last="Yang">Neng Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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